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Название: Antifibrotic and Regenerative Effects of Treamid in Pulmonary Fibrosis
Авторы: Skurikhin, Evgenii
Nebolsin, Vladimir
Widera, Darius
Ermakova, Natalia
Pershina, Olga
Pakhomova, Angelina
Krupin, Vyacheslav
Pan, Edgar
Zhukova, Mariia
Novikov, Fedor
Sandrikina, Lubov
Morozov, Sergey
Kubatiev, Aslan
Dygai, Alexander
Ключевые слова: pulmonary fibrosis
Treamid
regeneration
endothelial progenitor cells
Дата публикации: 8-ноя-2020
Издательство: MDPI
Серия/номер: International Journal of Molecular Sciences;Volume 21, Issue 21
Краткий осмотр (реферат): Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by interstitial fibrosis and progressive respiratory failure. Pirfenidone and nintedanib slow down but do not stop the progression of IPF. Thus, new compounds with high antifibrotic activity and simultaneously regenerative activity are an unmet clinical need. Recently, we showed that Treamid can help restoring the pancreas and testicular tissue in mice with metabolic disorders. We hypothesized that Treamid may be effective in antifibrotic therapy and regeneration of damaged lung tissue in pulmonary fibrosis. In this study, experiments were performed on male C57BL/6 mice with bleomycin-induced pulmonary fibrosis. We applied histological and immunohistochemical methods, ELISA, and assessed the expression of markers of endothelial and epithelial cells in primary cultures of CD31+ and CD326+ lung cells. Finally, we evaluated esterase activity and apoptosis of lung cells in vitro. Our data indicate that Treamid exhibits antifibrotic activity in mice with pulmonary fibrosis and has a positive effect on capillaries of the lungs. Treamid also increases the number of endothelial progenitor cells in the lungs of animals with pulmonary fibrosis. Lastly, Treamid increases esterase activity and decreases apoptosis of CD31+ lung cells in vitro. Based on these findings, we suggest that Treamid may represent a promising compound for the development of new antifibrotic agents, which are capable of stimulating regeneration of lung endothelium in IPF patients.
URI (Унифицированный идентификатор ресурса): https://doi.org/10.3390/ijms21218380
http://hdl.handle.net/20.500.12701/1881
Располагается в коллекциях:International Journal of Molecular Sciences

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