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dc.contributor.authorVonk, J. M.-
dc.contributor.authorScholtens, S.-
dc.contributor.authorPostma, D. S.-
dc.contributor.authorMoffatt, M. F.-
dc.contributor.authorJarvis, D.-
dc.contributor.authorRamasamy, A.-
dc.contributor.authorWjst, M.-
dc.contributor.authorOmenaas, E. R.-
dc.contributor.authorBouzigon, E.-
dc.contributor.authorDemenais, F.-
dc.contributor.authorNadif, R.-
dc.contributor.authorSiroux, V.-
dc.contributor.authorPolonikov, A. V.-
dc.contributor.authorSolodilova, M.-
dc.contributor.authorIvanov, V. P.-
dc.contributor.authorCurjuric, I.-
dc.contributor.authorImboden, M.-
dc.contributor.authorKumar, A.-
dc.contributor.authorProbst-Hensch, N.-
dc.contributor.authorOgorodova, L. M.-
dc.contributor.authorPuzyrev, V. P.-
dc.contributor.authorBragina, E. Yu-
dc.contributor.authorFreidin, M. B.-
dc.contributor.authorNolte, I. M.-
dc.contributor.authorFarrall, A. M.-
dc.contributor.authorCookson, W. O. C. M.-
dc.contributor.authorStrachan, D. P.-
dc.contributor.authorKoppelman, G. H.-
dc.contributor.authorBoezen, H. M.-
dc.date.accessioned2022-03-30T08:15:11Z-
dc.date.available2022-03-30T08:15:11Z-
dc.date.issued2017-03-02-
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0172716-
dc.identifier.urihttp://hdl.handle.net/20.500.12701/1760-
dc.description.abstractBackground Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma. Methods We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects. Results First approach: 50 SNPs were selected based on an overall interaction effect at p<10−4. The most pronounced interaction effect was observed for rs9969775 on chromosome 9 (discovery meta-analysis: ORint = 0.50, p = 7.63*10−5, replication: ORint = 0.65, p = 0.02). Second approach: 35 SNPs were selected based on the overall genetic effect in exposed subjects (p <10−4). The most pronounced genetic effect was observed for rs5011804 on chromosome 12 (discovery meta-analysis ORint = 1.50, p = 1.21*10−4; replication: ORint = 1.40, p = 0.03). Conclusions Using two genome-wide interaction approaches, we identified novel polymorphisms in non-annotated intergenic regions on chromosomes 9 and 12, that showed suggestive evidence for interaction with active tobacco smoking in the onset of adult asthma.ru_RU
dc.language.isoenru_RU
dc.publisherPLOSru_RU
dc.relation.ispartofseriesPLOS ONE;Volume 12, Issue 3-
dc.subjectSmoking habitsru_RU
dc.subjectAsthmaru_RU
dc.subjectMetaanalysisru_RU
dc.subjectSingle nucleotide polymorphismsru_RU
dc.subjectGeneticsru_RU
dc.subjectReplication studiesru_RU
dc.subjectSmoking related disordersru_RU
dc.subjectCohort studiesru_RU
dc.titleAdult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortiumru_RU
dc.typeArticleru_RU
Располагается в коллекциях:PLOS ONE

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