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Название: Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Авторы: Demenais, Florence
Margaritte-Jeannin, Patricia
Barnes, Kathleen C.
Cookson, William O. C.
Altmüller, Janine
Ang, Wei
Barr, R. Graham
Beaty, Terri H.
Becker, Allan B.
Beilby, John
Bisgaard, Hans
Bjornsdottir, Unnur Steina
Bleecker, Eugene
Bønnelykke, Klaus
Boomsma, Dorret I.
Bouzigon, Emmanuelle
Brightling, Christopher E.
Brossard, Myriam
Brusselle, Guy G.
Burchard, Esteban
Burkart, Kristin M.
Bush, Andrew
Chan-Yeung, Moira
Chung, Kian Fan
Couto Alves, Alexessander
Curtin, John A.
Custovic, Adnan
Daley, Denise
Jongste, Johan C.
Del-Rio-Navarro, Blanca E.
Donohue, Kathleen M.
Duijts, Liesbeth
Eng, Celeste
Eriksson, Johan G.
Farrall, Martin
Fedorova, Yuliya
Feenstra, Bjarke
Ferreira, Manuel A.
Australian Asthma Genetics, Consortium
Freidin, Maxim B.
Gajdos, Zofia
Gauderman, Jim
Gehring, Ulrike
Geller, Frank
Genuneit, Jon
Gharib, Sina A.
Gillil, Frank
Granell, Raquel
Graves, Penelope E.
Gudbjartsson, Daniel F.
Haahtela, Tari
Heckbert, Susan R.
Heederik, Dick
Heinrich, Joachim
Heliövaara, Markku
Henderson, John
Himes, Blanca E.
Hirose, Hiroshi
Hirschhorn, Joel N.
Hofman, Albert
Holt, Patrick
Hottenga, Jouke
Hudson, Thomas J.
Hui, Jennie
Imboden, Medea
Ivanov, Vladimir
Jaddoe, Vincent W. V.
James, Alan
Janson, Christer
Jarvelin, Marjo-Riitta
Jarvis, Deborah
Jones, Graham
Jonsdottir, Ingileif
Jousilahti, Pekka
Kabesch, Michael
Kähönen, Mika
Kantor, David B.
Karunas, Alexandra S.
Khusnutdinova, Elza
Koppelman, Gerard H.
Kozyrskyj, Anita L.
Kreiner, Eskil
Kubo, Michiaki
Kumar, Rajesh
Kumar, Ashish
Kuokkanen, Mikko
Lahousse, Lies
Laitinen, Tarja
Laprise, Catherine
Lathrop, Mark
Lau, Susanne
Lee, Young-Ae
Lehtimäki, Terho
Letort, Sébastien
Levin, Albert M.
Li, Guo
Liang, Liming
Loehr, Laura R.
London, Stephanie J.
Loth, Daan W.
Manichaikul, Ani
Marenholz, Ingo
Martinez, Fernando J.
Matheson, Melanie C.
Mathias, Rasika A.
Matsumoto, Kenji
Mbarek, Hamdi
McArdle, Wendy L.
Melbye, Mads
Melén, Erik
Meyers, Deborah
Michel, Sven
Mohamdi, Hamida
Musk, Arthur W.
Myers, Rachel A.
Nieuwenhuis, Maartje A. E.
Noguchi, Emiko
O’Connor, George T.
Ogorodova, Ludmila M.
Palmer, Cameron D.
Palotie, Aarno
Park, Julie E.
Pennell, Craig E.
Pershagen, Göran
Polonikov, Alexey
Postma, Dirkje S.
Probst-Hensch, Nicole
Puzyrev, Valery P.
Raby, Benjamin A.
Raitakari, Olli T.
Ramasamy, Adaikalavan
Rich, Stephen S.
Robertson, Colin F.
Romieu, Isabelle
Salam, Muhammad T.
Salomaa, Veikko
Schlünssen, Vivi
Scott, Robert
Selivanova, Polina A.
Sigsgaard, Torben
Siroux, Valérie
Simpson, Angela
Smith, Lewis J.
Solodilova, Maria
Standl, Marie
Stefansson, Kari
Strachan, David P.
Stricker, Bruno H.
Takahashi, Atsushi
Thompson, Philip J.
Thorleifsson, Gudmar
Thorsteinsdottir, Unnur
Tiesler, Carla M. T.
Torgerson, Dara G.
Tsunoda, Tatsuhiko
Uitterlinden, André G.
van der Valk, Ralf J. P.
Vaysse, Amaury
Vedantam, Sailaja
von Berg, Andrea
von Mutius, Erika
Vonk, Judith M.
Waage, Johannes
Wareham, Nick J.
Weiss, Scott T.
White, Wendy B.
Wickman, Magnus
Widén, Elisabeth
Willemsen, Gonneke
Williams, L. Keoki
Wouters, Inge M.
Yang, James J.
Zhao, Jing Hua
Moffatt, Miriam F.
Ober, Carole
Nicolae, Dan L.
Ключевые слова: Asthma
Genome-wide association studies
Дата публикации: 22-дек-2017
Издательство: Springer Nature
Серия/номер: Nature Genetics;Volume 50
Краткий осмотр (реферат): We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
URI (Унифицированный идентификатор ресурса): https://doi.org/10.1038/s41588-017-0014-7
http://hdl.handle.net/20.500.12701/1741
Располагается в коллекциях:Nature Genetics

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