Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на этот ресурс: http://hdl.handle.net/20.500.12701/1722
Название: Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart
Авторы: Mukhamadiyarov, Rinat A.
Senokosova, Evgeniya A.
Krutitsky, Sergey S.
Voevoda, Darya V.
Pyshnaya, Inna A.
Ivanov, Vladimir V.
Lewis, Martin J.
Khaliulin, Igor
Ключевые слова: drug delivery
heart
size of liposomes
myocardial accumulation and distribution
cardiac ischemia/reperfusion injury
cardioprotection
Дата публикации: сен-2018
Издательство: Wolters Kluwer Health
Серия/номер: ​​​Journal of Cardiovascular Pharmacology;Volume 72, Issue 3
Краткий осмотр (реферат): Liposomes have the potential to be used for drug delivery. Meanwhile, liposome size may affect their accumulation in the target tissue. We investigated the myocardial accumulation of 2 populations of liposomes (∼70 and 110 nm diameter) during ischemia and their effect on ischemia/reperfusion injury. Isolated rat hearts were subjected to 30 minutes of low-flow ischemia with the liposomes, followed by 30 minutes of liposome-free reperfusion. The liposomes were loaded with the fluorescent dye Nile Red to assess their accumulation in the myocardium. The cardiac functional recovery during reperfusion was evaluated using force–velocity characteristics and coronary flow (CF). Reperfusion injury was evaluated by lactate dehydrogenase release. In addition, CF and contractility were assessed in hearts perfused normally with 70 nm liposomes. There was a 6- and 4-fold greater accumulation of the small liposomes in the myocardium and mitochondria, respectively, compared with the large liposomes. Importantly, even without any incorporated drugs, both populations of liposomes improved functional recovery and reduced lactate dehydrogenase release. However, the smaller liposomes showed significantly higher protective and vasodilatory effects during reperfusion than the larger particles. These liposomes also increased CF and contractility during normal perfusion. We suggest that the protective properties of the liposomes could be related to their membrane-stabilizing effect.
URI (Унифицированный идентификатор ресурса): https://doi.org/10.1097/FJC.0000000000000606
http://hdl.handle.net/20.500.12701/1722
Располагается в коллекциях:​​​Journal of Cardiovascular Pharmacology

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