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Название: Biological markers and cardiac remodelling following the myocardial infarction
Авторы: Gruzdeva, Olga
Dyleva, Yulia
Uchasova, Evgenya
Akbasheva, Olga
Karetnikova, Victoria
Kashtalap, Vasiliy
Shilov, Aleksandr
Polikutina, Olga
Slepynina, Yulia
Barbarash, Olga
Ключевые слова: postinfarction remodelling
growth stimulating factor ST2
NT-proBNP
myocardial infraction
Дата публикации: 10-июн-2019
Издательство: Impact Journals, LLC
Серия/номер: Aging;Volume 11, Issue 11
Краткий осмотр (реферат): Aim: To assess growth stimulating factor ST2 and N-terminal pro b-type natriuretic peptide (NT-proBNP) levels in the sera of myocardial infraction (MI) patients, and their correlation with the adaptive and maladaptive variants of cardiac remodelling. Methods: 87 patients (65 male, 22 females; 67±8.36 years) with ST-elevated MI were included in this study, and 67 patients had an adaptive, physiological, while 20 patients had a maladaptive, pathological variant of myocardium remodelling. Results: On day 1, ST2 and NT-proBNP levels were shown to increase 2.4 and 4.5 folds, respectively, compared with those in the control. ST2 levels in patients with maladaptive remodelling were 1.5-fold higher than those in the adaptive remodelling group. On day 12, a decrease in ST2 levels was observed in both groups. NT-proBNP levels increased 1.8 folds in both groups on day 1, compared with those in the controls. Increased ST2 levels on day 1 after MI were shown to increase the risk of maladaptive remodelling 4.5 folds, while high NT-proBNP levels increased this risk 2.3 times. Conclusions: ST2 level determination allows us to predict the risk of maladaptive remodelling with a higher sensitivity and specificity than using NT-proBNP levels.
URI (Унифицированный идентификатор ресурса): https://doi.org/10.18632/aging.101994
http://hdl.handle.net/20.500.12701/1700
Располагается в коллекциях:Aging

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