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Название: Markers of Cancer Cell Invasion: Are They Good Enough?
Авторы: Gerashchenko, Tatiana S.
Novikov, Nikita M.
Krakhmal, Nadezhda V.
Zolotaryova, Sofia Y.
Zavyalova, Marina V.
Cherdyntseva, Nadezhda V.
Denisov, Evgeny V.
Perelmuter, Vladimir M.
Ключевые слова: cancer
invasion
invasive front
epithelial–mesenchymal transition
heterogeneity
Дата публикации: 24-июл-2019
Издательство: MDPI
Краткий осмотр (реферат): Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of cancer and the first step towards metastasis. Penetrating to adjacent tissues, tumor cells form the so-called invasive front/edge. The cellular plasticity afforded by different kinds of phenotypic transitions (epithelial–mesenchymal, collective–amoeboid, mesenchymal–amoeboid, and vice versa) significantly contributes to the diversity of cancer cell invasion patterns and mechanisms. Nevertheless, despite the advances in the understanding of invasion, it is problematic to identify tumor cells with the motile phenotype in cancer tissue specimens due to the absence of reliable and acceptable molecular markers. In this review, we summarize the current information about molecules such as extracellular matrix components, factors of epithelial–mesenchymal transition, proteases, cell adhesion, and actin cytoskeleton proteins involved in cell migration and invasion that could be used as invasive markers and discuss their advantages and limitations. Based on the reviewed data, we conclude that future studies focused on the identification of specific invasive markers should use new models one of which may be the intratumor morphological heterogeneity in breast cancer reflecting different patterns of cancer cell invasion
URI (Унифицированный идентификатор ресурса): https://doi.org/10.3390/jcm8081092
http://hdl.handle.net/20.500.12701/1684
Располагается в коллекциях:Journal of Clinical Medicine

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