http://hdl.handle.net/20.500.12701/2028 Human Psychopharmacology: Clinical and Experimental provides a forum for the evaluation of clinical and experimental research on both new and established psychotropic medicines. Fri, 03 May 2024 12:21:00 GMT 2024-05-03T12:21:00Z http://hdl.handle.net/20.500.12701/2029 Название: Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia Авторы: Fedorenko, Olga Yu.; Paderina, Diana Z.; Loonen, Anton J. M.; Pozhidaev, Ivan V.; Boiko, Anastasiia S.; Kornetova, Elena G.; Bokhan, Nikolay A.; Wilffert, Bob; Ivanova, Svetlana A. Краткий осмотр (реферат): Schizophrenia is a severe highly heritable mental disorder. Genetic polymorphisms of dopaminergic pathways are related to pathogenesis of drug response. Hyperprolactinemia (HPRL), a common adverse effect of antipsychotics, is attributed to blockade of dopamine D2 receptors. Ankyrin Repeat and Kinase Domain containing 1 (ANKK1) gene is closely related to Dopamine Receptor D2 type (DRD2) gene functioning. We examined whether the functional polymorphism rs2734849 in the ANKK1 gene is associated with antipsychotic-induced HPRL. Fri, 08 May 2020 00:00:00 GMT http://hdl.handle.net/20.500.12701/2029 2020-05-08T00:00:00Z