http://hdl.handle.net/20.500.12701/1840 Translational Psychiatry bridges this gap by focusing on papers that directly study psychiatric disorders and bring new discovery into clinical practice. Fri, 03 May 2024 12:23:20 GMT 2024-05-03T12:23:20Z http://hdl.handle.net/20.500.12701/1841 Название: NMDA receptor genotypes associated with the vulnerability to develop dyskinesia Авторы: Ivanova, S. A.; Loonen, A. J. M.; Pechlivanoglou, P.; Freidin, M. B.; Al Hadithy, A. F. Y.; Rudikov, E. V.; Zhukova, I. A.; Govorin, N. V.; Sorokina, V. A.; Fedorenko, O. Y.; Alifirova, V. M.; Semke, A. V.; Brouwers, J. R. B. J.; Wilffert, B. Краткий осмотр (реферат): Dyskinesias are involuntary muscle movements that occur spontaneously in Huntington's disease (HD) and after long-term treatments for Parkinson's disease (levodopa-induced dyskinesia; LID) or for schizophrenia (tardive dyskinesia, TD). Previous studies suggested that dyskinesias in these three conditions originate from different neuronal pathways that converge on overstimulation of the motor cortex. We hypothesized that the same variants of the N-methyl-D-aspartate receptor gene that were previously associated with the age of dyskinesia onset in HD were also associated with the vulnerability for TD and not LID. Genotyping patients with LID and TD revealed, however, that these two variants were dose-dependently associated with susceptibility to LID, but not TD. This suggested that LID, TD and HD might arise from the same neuronal pathways, but TD results from a different mechanism. Tue, 10 Jan 2012 00:00:00 GMT http://hdl.handle.net/20.500.12701/1841 2012-01-10T00:00:00Z