http://hdl.handle.net/20.500.12701/1784 Genes & Diseases is an international journal for molecular and translational medicine. Fri, 03 May 2024 12:27:26 GMT 2024-05-03T12:27:26Z http://hdl.handle.net/20.500.12701/1820 Название: NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension Авторы: Orlov, Sergei N.; Koltsova, Svetlana V.; Kapilevich, Leonid V.; Gusakova, Svetlana V.; Dulind, Nickolai O. Краткий осмотр (реферат): This review summarizes the data on the functional significance of ubiquitous (NKCC1) and renal-specific (NKCC2) isoforms of electroneutral sodium, potassium and chloride cotransporters. These carriers contribute to the pathogenesis of hypertension via regulation of intracellular chloride concentration in vascular smooth muscle and neuronal cells and via sensing chloride concentration in the renal tubular fluid, respectively. Both NKCC1 and NKCC2 are inhibited by furosemide and other high-ceiling diuretics widely used for attenuation of extracellular fluid volume. However, the chronic usage of these compounds for the treatment of hypertension and other volume-expanded disorders may have diverse side-effects due to suppression of myogenic response in microcirculatory beds. Wed, 25 Feb 2015 00:00:00 GMT http://hdl.handle.net/20.500.12701/1820 2015-02-25T00:00:00Z http://hdl.handle.net/20.500.12701/1785 Название: Skeletal muscle as an endocrine organ: Role of [Na+]i/[K+]i-mediated excitation-transcription coupling Авторы: Kapilevich, Leonid V.; Kironenko, Tatyana A.; Zaharova, Anna N.; Kotelevtsev, Yuri V.; Dulin, Nickolai O.; Orlov, Sergei N. Краткий осмотр (реферат): During the last two decades numerous research teams demonstrated that skeletal muscles function as an exercise-dependent endocrine organ secreting dozens of myokines. Variety of physiological and pathophysiological implications of skeletal muscle myokines secretion has been described; however, upstream signals and sensing mechanisms underlying this phenomenon remain poorly understood. It is well documented that in skeletal muscles intensive exercise triggers dissipation of transmembrane gradient of monovalent cations caused by permanent activation of voltage-gated Na+ and K+ channels. Recently, we demonstrated that sustained elevation of the [Na+]i/[K+]i ratio triggers expression of dozens ubiquitous genes including several canonical myokines, such as interleukin-6 and cyclooxygenase 2, in the presence of intra- and extracellular Ca2+ chelators. These data allowed us to suggest a novel [Na+]i/[K+]i-sensitive, Ca2+i-independent mechanism of excitation-transcription coupling which triggers myokine production. This pathway exists in parallel with canonical signaling mediated by Ca2+i, AMP-activated protein kinase and hypoxia-inducible factor 1α (HIF-1α). In our mini-review we briefly summarize data supporting this hypothesis as well as unresolved issues aiming to forthcoming studies. Wed, 21 Oct 2015 00:00:00 GMT http://hdl.handle.net/20.500.12701/1785 2015-10-21T00:00:00Z