http://hdl.handle.net/20.500.12701/1776 Annals of Laboratory Medicine (Ann Lab Med; ISSN, 2234-3806; e-ISSN, 2234-3814) is the official journal of Korean Society for Laboratory Medicine. 2024-02-18T20:58:33Z http://hdl.handle.net/20.500.12701/1777 Название: Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction Авторы: Barbarash, Olga; Gruzdeva, Olga; Uchasova, Evgenya; Dyleva, Yulia; Belik, Ekaterina; Akbasheva, Olga; Karetnikova, Victoria; Shilov, Aleksandr Краткий осмотр (реферат): Background: Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications. Methods: We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups: the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA. Results: On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004). Conclusions: The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP. 2016-07-01T00:00:00Z