DSpace Собрание: Nature Genetics is a monthly journal publishing the best research from across the field of genetics, with our broad scope ensuring that work published reaches the widest possible audience. All editorial decisions are made by a team of full-time professional editors.
http://hdl.handle.net/20.500.12701/1740
Nature Genetics is a monthly journal publishing the best research from across the field of genetics, with our broad scope ensuring that work published reaches the widest possible audience. All editorial decisions are made by a team of full-time professional editors.2024-02-17T05:11:04ZMultiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
http://hdl.handle.net/20.500.12701/1741
Название: Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Авторы: Demenais, Florence; Margaritte-Jeannin, Patricia; Barnes, Kathleen C.; Cookson, William O. C.; Altmüller, Janine; Ang, Wei; Barr, R. Graham; Beaty, Terri H.; Becker, Allan B.; Beilby, John; Bisgaard, Hans; Bjornsdottir, Unnur Steina; Bleecker, Eugene; Bønnelykke, Klaus; Boomsma, Dorret I.; Bouzigon, Emmanuelle; Brightling, Christopher E.; Brossard, Myriam; Brusselle, Guy G.; Burchard, Esteban; Burkart, Kristin M.; Bush, Andrew; Chan-Yeung, Moira; Chung, Kian Fan; Couto Alves, Alexessander; Curtin, John A.; Custovic, Adnan; Daley, Denise; Jongste, Johan C.; Del-Rio-Navarro, Blanca E.; Donohue, Kathleen M.; Duijts, Liesbeth; Eng, Celeste; Eriksson, Johan G.; Farrall, Martin; Fedorova, Yuliya; Feenstra, Bjarke; Ferreira, Manuel A.; Australian Asthma Genetics, Consortium; Freidin, Maxim B.; Gajdos, Zofia; Gauderman, Jim; Gehring, Ulrike; Geller, Frank; Genuneit, Jon; Gharib, Sina A.; Gillil, Frank; Granell, Raquel; Graves, Penelope E.; Gudbjartsson, Daniel F.; Haahtela, Tari; Heckbert, Susan R.; Heederik, Dick; Heinrich, Joachim; Heliövaara, Markku; Henderson, John; Himes, Blanca E.; Hirose, Hiroshi; Hirschhorn, Joel N.; Hofman, Albert; Holt, Patrick; Hottenga, Jouke; Hudson, Thomas J.; Hui, Jennie; Imboden, Medea; Ivanov, Vladimir; Jaddoe, Vincent W. V.; James, Alan; Janson, Christer; Jarvelin, Marjo-Riitta; Jarvis, Deborah; Jones, Graham; Jonsdottir, Ingileif; Jousilahti, Pekka; Kabesch, Michael; Kähönen, Mika; Kantor, David B.; Karunas, Alexandra S.; Khusnutdinova, Elza; Koppelman, Gerard H.; Kozyrskyj, Anita L.; Kreiner, Eskil; Kubo, Michiaki; Kumar, Rajesh; Kumar, Ashish; Kuokkanen, Mikko; Lahousse, Lies; Laitinen, Tarja; Laprise, Catherine; Lathrop, Mark; Lau, Susanne; Lee, Young-Ae; Lehtimäki, Terho; Letort, Sébastien; Levin, Albert M.; Li, Guo; Liang, Liming; Loehr, Laura R.; London, Stephanie J.; Loth, Daan W.; Manichaikul, Ani; Marenholz, Ingo; Martinez, Fernando J.; Matheson, Melanie C.; Mathias, Rasika A.; Matsumoto, Kenji; Mbarek, Hamdi; McArdle, Wendy L.; Melbye, Mads; Melén, Erik; Meyers, Deborah; Michel, Sven; Mohamdi, Hamida; Musk, Arthur W.; Myers, Rachel A.; Nieuwenhuis, Maartje A. E.; Noguchi, Emiko; O’Connor, George T.; Ogorodova, Ludmila M.; Palmer, Cameron D.; Palotie, Aarno; Park, Julie E.; Pennell, Craig E.; Pershagen, Göran; Polonikov, Alexey; Postma, Dirkje S.; Probst-Hensch, Nicole; Puzyrev, Valery P.; Raby, Benjamin A.; Raitakari, Olli T.; Ramasamy, Adaikalavan; Rich, Stephen S.; Robertson, Colin F.; Romieu, Isabelle; Salam, Muhammad T.; Salomaa, Veikko; Schlünssen, Vivi; Scott, Robert; Selivanova, Polina A.; Sigsgaard, Torben; Siroux, Valérie; Simpson, Angela; Smith, Lewis J.; Solodilova, Maria; Standl, Marie; Stefansson, Kari; Strachan, David P.; Stricker, Bruno H.; Takahashi, Atsushi; Thompson, Philip J.; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tiesler, Carla M. T.; Torgerson, Dara G.; Tsunoda, Tatsuhiko; Uitterlinden, André G.; van der Valk, Ralf J. P.; Vaysse, Amaury; Vedantam, Sailaja; von Berg, Andrea; von Mutius, Erika; Vonk, Judith M.; Waage, Johannes; Wareham, Nick J.; Weiss, Scott T.; White, Wendy B.; Wickman, Magnus; Widén, Elisabeth; Willemsen, Gonneke; Williams, L. Keoki; Wouters, Inge M.; Yang, James J.; Zhao, Jing Hua; Moffatt, Miriam F.; Ober, Carole; Nicolae, Dan L.
Краткий осмотр (реферат): We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.2017-12-22T00:00:00Z