Pediatric Allergy and Immunology is the world's leading journal in pediatric allergy, publishing original contributions and comprehensive reviews related to the understanding and treatment of immune deficiency and allergic inflammatory and infectious diseases in children. http://hdl.handle.net/20.500.12701/1869 2024-05-03T12:20:04Z 2024-05-03T12:20:04Z De Blic, Jacques Ogorodova, Ludmila Klink, Rabih Sidorenko, Irina Valiulis, Arunas Hofman, Jerzy Bennedbaek, Olav Anderton, Sally Attali, Valerie Desfougeres, Jean-Luc Poterre, Marc http://hdl.handle.net/20.500.12701/1870 2022-04-06T05:36:41Z 2009-11-30T00:00:00Z

Название: Salmeterol/fluticasone propionate vs. double dose fluticasone propionate on lung function and asthma control in children Авторы: De Blic, Jacques; Ogorodova, Ludmila; Klink, Rabih; Sidorenko, Irina; Valiulis, Arunas; Hofman, Jerzy; Bennedbaek, Olav; Anderton, Sally; Attali, Valerie; Desfougeres, Jean-Luc; Poterre, Marc Краткий осмотр (реферат): There is a large body of data to support the use of an inhaled corticosteroid (ICS) plus a long-acting β2-agonist vs. increasing the dose of ICS in adults, but less data in children. This double-blind, parallel group, non-inferiority study compared lung function and asthma control, based on Global Initiative for Asthma guidelines, in children receiving either salmeterol/fluticasone propionate (SFC) 50/100 μg bd (n = 160) or fluticasone propionate (FP) 200 μg bd (n = 161) for 12 wks. Change from baseline in mean morning peak expiratory flow increased following both treatments, but was significantly greater in the SFC group compared with FP [Adjusted mean change (s.e.) (l/min): SFC: 26.9 (2.13), FP: 19.3 (2.12); treatment difference: 7.6 (3.01); 95% CI: 1.7, 13.5; p = 0.012)]. Asthma control improved over time in both groups. Mean pre-bronchodilator maximal-expiratory flow at 50% vital capacity and percentage rescue-free days showed significantly greater improvements in the SFC group compared with FP. All other efficacy indices showed comparable improvements in each group. Treatment with SFC 50/100 μg bd compared with twice the steroid dose of FP (200 μg bd), was at least as effective in improving individual clinical outcomes and overall asthma control, in asthmatic children previously uncontrolled on low doses of ICS.

2009-11-30T00:00:00Z