Biochemical and Biophysical Research Communications is the premier international journal devoted to the very rapid dissemination of timely and significant experimental results in diverse fields of biological research. http://hdl.handle.net/20.500.12701/1818 2024-05-03T12:20:23Z 2024-05-03T12:20:23Z Yuryeva, Ksenia Saltykova, Irina Ogorodova, Ludmila Kirillova, Natalya Kulikov, Evgeny Korotkaya, Elena Iakovleva, Yulia Feoktistov, Igor Sazonov, Alexey Ryzhov, Sergey http://hdl.handle.net/20.500.12701/1819 2022-04-04T05:11:09Z 2015-09-04T00:00:00Z

Название: Expression of adenosine receptors in monocytes from patients with bronchial asthma Авторы: Yuryeva, Ksenia; Saltykova, Irina; Ogorodova, Ludmila; Kirillova, Natalya; Kulikov, Evgeny; Korotkaya, Elena; Iakovleva, Yulia; Feoktistov, Igor; Sazonov, Alexey; Ryzhov, Sergey Краткий осмотр (реферат): Adenosine is generated from adenosine triphosphate, which is released by stressed and damaged cells. Adenosine levels are significantly increased in patients with bronchial asthma (BA) and mediate mast cell degranulation and bronchoconstriction. Over the last decade, increasing evidence has shown that adenosine can modulate the innate immune response during monocytes differentiation towards mature myeloid cells. These adenosine-differentiated myeloid cells, characterized by co-expression of monocytes/macrophages and dendritic cell markers such as CD14 and CD209, produce high levels of pro-inflammatory cytokines, thus contributing to the pathogenesis of BA and chronic obstructive pulmonary disease. We found that expression of ADORA2A and ADORA2B are increased in monocytes obtained from patients with BA, and are associated with the generation of CD14posCD209pos pro-inflammatory cells. A positive correlation between expression of ADORA2B and IL-6 was identified in human monocytes and may explain the increased expression of IL-6 mRNA in asthmatics. Taken together, our results suggest that monocyte-specific expression of A2 adenosine receptors plays an important role in pro-inflammatory activation of human monocytes, thus contributing to the progression of asthma.

2015-09-04T00:00:00Z