DSpace Собрание: American Journal of Respiratory Cell and Molecular Biology Publishes the most significant and original observations in the area of respiratory and lung cell biologyAmerican Journal of Respiratory Cell and Molecular Biology Publishes the most significant and original observations in the area of respiratory and lung cell biologyhttp://hdl.handle.net/20.500.12701/17052024-02-19T01:15:58Z2024-02-19T01:15:58ZSustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-βArd, ShawnReed, Eleanor B.Smolyaninova, Larisa V.Orlov, Sergei N.Mutlu, Gökhan M.Guzy, Robert D.Dulin, Nickolai O.http://hdl.handle.net/20.500.12701/17062022-03-22T08:28:18Z2019-03-01T00:00:00ZНазвание: Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β
Авторы: Ard, Shawn; Reed, Eleanor B.; Smolyaninova, Larisa V.; Orlov, Sergei N.; Mutlu, Gökhan M.; Guzy, Robert D.; Dulin, Nickolai O.
Краткий осмотр (реферат): Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease characterized by parenchymal fibrosis and structural distortion of the lungs. IPF is believed to be a disorder of abnormal wound healing, wherein the initial trigger to the fibrotic response is injury to the alveolar epithelial cells, followed by an exuberant, nonresolving wound-healing response (1). Injury of alveolar epithelial cells results in the elaboration of a fibrinous matrix and activation of several profibrotic mediators, of which transforming growth factor β (TGF-β) is the most established. Lung-targeted overexpression of TGF-β results in the development of lung fibrosis in animals. Conversely, inhibition of TGF-β can inhibit in vivo fibrogenesis...2019-03-01T00:00:00Z