DSpace Собрание: Journal of Clinical Medicine is an international, peer-reviewed, open access journal of clinical medicine, published semimonthly online by MDPIJournal of Clinical Medicine is an international, peer-reviewed, open access journal of clinical medicine, published semimonthly online by MDPIhttp://hdl.handle.net/20.500.12701/16832024-03-29T15:43:59Z2024-03-29T15:43:59ZBeta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid DepressionRoschina, Olga V.Levchuk, Lyudmila A.Boiko, Anastasiia S.Michalitskaya, Ekaterina V.Epimakhova, Elena V.Losenkov, Innokentiy S.Simutkin, German G.Loonen, Anton J. M.Bokhan, Nikolay A.Ivanova, Svetlana A.http://hdl.handle.net/20.500.12701/21412022-06-24T11:37:48Z2021-12-03T00:00:00ZНазвание: Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression
Авторы: Roschina, Olga V.; Levchuk, Lyudmila A.; Boiko, Anastasiia S.; Michalitskaya, Ekaterina V.; Epimakhova, Elena V.; Losenkov, Innokentiy S.; Simutkin, German G.; Loonen, Anton J. M.; Bokhan, Nikolay A.; Ivanova, Svetlana A.
Краткий осмотр (реферат): Background: The neuropeptides β-endorphin and oxytocin are released into the bloodstream as hormones from the pituitary gland but also have an important function as neuroregulators in the forebrain. The blood levels of both polypeptides have been shown to reflect depressive symptoms. β-Endorphin, in particular, is also involved in abstinence from alcohol. Methods: The serum levels of β-endorphin and oxytocin were measured during the early withdrawal phase in patients with alcohol use disorder (AUD) with (N = 35) or without (N = 45) depressive comorbidity and compared with those in healthy volunteers (N = 23). In addition to comparing the groups, the study examined whether serum levels correlated with various psychometric measures of dependence, depression and aggression, as well as with clinical characteristics of dependence. Results: Both serum levels of beta-endorphin and oxytocin were significantly lower in patients than those in healthy controls (p = 0.011 for β-endorphin and p = 0.005 for oxytocin, Kruskal–Wallis test). In patients with depressive comorbidity, the significance was greatest (p = 0.005 for β-endorphin and p = 0.004 for oxytocin, U-test). There was no correlation with clinical or psychometric parameters (p > 0.05, Spearman test), but beta-endorphin levels did correlate significantly with physical aggression (p = 0.026, Spearman test). Conclusions: Serum levels of β-endorphin and oxytocin are lower in patients with AUD, particularly in those with depressive comorbidity. β-Endorphin levels correlated with physical aggression according to the Buss–Durkee (BDHI) estimates.2021-12-03T00:00:00ZMarkers of Cancer Cell Invasion: Are They Good Enough?Gerashchenko, Tatiana S.Novikov, Nikita M.Krakhmal, Nadezhda V.Zolotaryova, Sofia Y.Zavyalova, Marina V.Cherdyntseva, Nadezhda V.Denisov, Evgeny V.Perelmuter, Vladimir M.http://hdl.handle.net/20.500.12701/16842022-03-16T08:02:06Z2019-07-24T00:00:00ZНазвание: Markers of Cancer Cell Invasion: Are They Good Enough?
Авторы: Gerashchenko, Tatiana S.; Novikov, Nikita M.; Krakhmal, Nadezhda V.; Zolotaryova, Sofia Y.; Zavyalova, Marina V.; Cherdyntseva, Nadezhda V.; Denisov, Evgeny V.; Perelmuter, Vladimir M.
Краткий осмотр (реферат): Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of cancer and the first step towards metastasis. Penetrating to adjacent tissues, tumor cells form the so-called invasive front/edge. The cellular plasticity afforded by different kinds of phenotypic transitions (epithelial–mesenchymal, collective–amoeboid, mesenchymal–amoeboid, and vice versa) significantly contributes to the diversity of cancer cell invasion patterns and mechanisms. Nevertheless, despite the advances in the understanding of invasion, it is problematic to identify tumor cells with the motile phenotype in cancer tissue specimens due to the absence of reliable and acceptable molecular markers. In this review, we summarize the current information about molecules such as extracellular matrix components, factors of epithelial–mesenchymal transition, proteases, cell adhesion, and actin cytoskeleton proteins involved in cell migration and invasion that could be used as invasive markers and discuss their advantages and limitations. Based on the reviewed data, we conclude that future studies focused on the identification of specific invasive markers should use new models one of which may be the intratumor morphological heterogeneity in breast cancer reflecting different patterns of cancer cell invasion2019-07-24T00:00:00Z